Scientific Publications

 

  1. Hahn T., Szabo L., Gold M., Ramanathapuram L., Hurely LH., and Akporiaye E.T.. Dietary administration of the pro-apoptotic vitamin E analog alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer. Cancer Res. 66: 9374-9378, 2006.

  2. Neuzil J, Dong LF, Ramanathapuram L, Hahn T, Chladova M, Wang XF, Zobalova R, Prochazka L, Gold M, Freeman R, Turanek J, Akporiaye E.T., Dyason JC, Ralph SJ. Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. Mol Aspects Med. 2007 Oct-Dec;28(5-6):607-45. Epub 2007 Feb 23. Review. PMID:17499351.

  3. Dong, L-F., E. Swettenham, J. Eliasson, X-F Wang, M. Gold, Y. Medunic, M. Stantic, P. Low, L. Prochazka, PK Witting, J. Turanek, E.T. Akporiaye, S.J. Ralph, and J. Neuzil. Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: The role of oxidative stress. Cancer Res. 67: 11906-11913, 2007.

  4. Hahn T, Fried K, Hurley LH and Akporiaye E.T. Orally Active a-TEA Suppresses Tumor Growth and Multiplicity of Spontaneous Murine Breast Cancer. Molecular Cancer Therapeutics. Jun;8(6):1570-8. Epub Jun 9, 2009. PMID: 19509249 NIHMS: 477064.

  5. Hahn T, Jagadish B, Mash EA, Garrison K, and Akporiaye E.T. Alpha-tocopheryloxyacetic acid: A novel chemotherapeutic that stimulates the anti-tumor immune response. Breast Cancer Res. 13(1):R4. 2011 PMCID: PMC3109570.

  6. Hahn T, Polanczyk MJ, Borodovsky A, Ramanathapuram LV, Akporiaye E.T., Ralph SJ. Use of anti-cancer drugs, mitocans, to enhance the immune responses against tumors. Current Pharmaceutical Biotechnology 2013. 14:357-376. PMID: 22201597.

  7. Hahn, T, Bradley-Dunlop D, Hurley LH, Von-Hoff D, Gately S, Disis ML, Lu H, Penichet ML, Besselsen DG, Cole, BB, Meeuwsen, T, Walker EB, Akporiaye, E.T. The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer. BMC Cancer. 2011. Nov.11:471. PMID: 22044845.

  8. Dong LF, Grant G, Massa H, Zobalova R, Akporiaye E.T., Neuzil J. α-Tocopheryloxyacetic acid is superior to α-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability.Int J Cancer. 2011 Oct 31. doi: 10.1002/ijc.26489. 2012 Sep 1: 131(5):1052-1058. PMID:22038845.

  9. Hahn T, Akporiaye E.T. Repeat dose study of the novel proapoptotic chemotherapeutic agent alpha-tocopheryloxy acetic acid in mice. Anticancer Drugs. 2012 Apr;23(4):455-64. doi: 1097/CAD.0b013e32834f6271. PMID:22185820.

  10. Li, Y, Hahn, T, Garrison, K, Cui, ZH, Thorburn, A, Thorburn, J, Hu, HM, Akporiaye, E.T. The vitamin E analog alpha-TEA stimulates tumor autophagy and enhances antigen cross-presentation. Cancer Res 2012 - doi: 10.1158/0008-5472.CAN-11-3103 PMCID: PMC3576035.

  11. Rodríguez-Enríquez S, Hernández-Esquivel L, Marín-Hernández A, Dong LF, Akporiaye E.T., Neuzil J, Ralph SJ, Moreno-Sánchez R. Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue. Biochim Biophys Acta. 2012 May 21. [Epub ahead of print], PMID: 22627082.

  12. Hahn T, Akporiaye ET. α-TEA as a stimulator of tumor autophagy and enhancer of antigen cross-presentation. Autophagy. 2013 Mar 1; 9(3):429-431. PMID: 23235369.

  13. Guerrouahen BS, Hahn T, Alderman Z, Curti B, Urba W, Akporiaye ET. GMP-grade α-TEA lysine salt: A 28-Day Oral Toxicity and Toxicokinetic Study with a 28-Day Recovery Period in Beagle Dogs. BMC Cancer. 2016 Mar 8;16:199. doi: 10.1186/s12885-016-2220-6.

  14. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.